How is p21 able to inhibit progression through the cell cycle?



Answers:
Yes, p21 can inhibit progression through cell cycle.
p21 is an inhibitor of CdK4/cyclinD, CdK6/cyclinD, CdK2/cyclinA, CdK2/cyclinE.
These CdK/cyclin proteins( they are kind of protein kinases) control the various mitotic checkpoints in the eukaryotic animal cell.
Good question. It's a complicated cycle but check out this web site:

http://jasn.asnjournals.org/cgi/content/.

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